© 2020 by TurnCare, Inc. 

Evidence

Ischemia / reperfusion (I/R) injury is well-known to result in negative health implications in the brain, heart, and other major organs and limbs. But what about when it occurs in the sacral region?

Current literature links sacral-region I/R injury to pressure injury formation and delayed wound healing. Evidence also suggests sacral-region I/R injury can contribute to patient pain and an overall systemic inflammatory response.

Force compresses vasculature

Compressed vessels impede circulation

Ischemia / reperfusion injury occurs

 
 
Sacral-region Pressure Injury Prevention
Guardian showed an 81% reduction in hospital acquired sacral-region pressure injuries in high-risk, acute care patients
2 vs. 11 sacral-region hospital-acquired pressure injuries
 
399-patient randomized, controlled trial
high-acuity patients with Braden 16 or less
Guardian compared to alternating pressure beds
published in the Journal of Wound, Ostomy, and Continence Nursing, July 2018
Length of Stay Reduction
Guardian showed a 57% length of stay reduction for mobility impaired stroke and acute kidney injury patients
observed in the 399-patient randomized, controlled trial focused on PI prevention
high-acuity patients with Braden 16 or less
unexpected and profound LOS benefit thought to be  a result of preventing sacral-region I/R injury and subsequent pro-inflammatory mediator release
Stage 2 Sacral-region Pressure Injury Treatment
Guardian showed 60% faster time to completely heal stage 2 sacral-region pressure injuries
10.5 vs. 26.5 days on average to complete healing
 
30 patient historical control study
patients residing in four community-based long-term care facilities
Guardian compared to organization-wide standard of care
 
Resources

Doll DN, Barr TL, Simpkins JW. Cytokines: Their role in stroke and potential use as biomarkers and therapeutic targets. Aging and Disease. 2014;5(5);294-306.

Eltzschig HK, Eckle T. Ischemia and reperfusion–from mechanism to translation. Nature medicine. 2011;17:1391–1401.

Kalogeris T, Baines CP, Krenz, M, Korthuis, RJ. Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol. 2012;298;229-317. 

Payen D, Lukaszewicz AC, Legrand M, Gayat E, Faiyre V, et al. A multicentre study of acute kidney injury in severe sepsis and septic shock: Association with inflammatory phenotype and HLA genotype. PLos ONE. 2012;7(6);e35838.

Pierce SM, Skalak TC, Rodeheaver GT. Ischemia-reperfusion injury in chronic pressure ulcer formation: a skin model in the rat. Wound Repair and Regeneration. 2000;8(1);68-76.

Truong A, Fan E, Brower R, Needham D. Bench-to-bedside review: mobilizing patients in the intensive care unit—from pathophysiology to clinical trials. Crit Care. 2009;13:216.

Zhang JM, An J. Cytokines, inflammation, and pain. International anesthesiology clinics. 2007;45(2);27-37.

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